PEPTIDES AND PEPTOIDS

Recent work in this area

D Gimenez, G Zhou, MFD Hurley, JA Aguilar, VA Voelz,* SL Cobb* “Fluorinated Aromatic Monomers as Building Blocks To Control α-Peptoid Conformation and Structure” J. Am. Chem. Soc., 2019, 141 (8), 3430-3434

D. Gimenez., J.A. Aguilar., E.H.C. Bromley., S.L. Cobb* “Stabilising Peptoid Helices Using Non-Chiral Fluoroalkyl Monomers” Angew. Chem. Int. Ed. 2018, 57, 10549 –10553

Want to make peptoids? Check out our group's practical demo here.

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INFECTIOUS DISEASES

Recent work in this area

HL. Bolt, G.A. Eggimann, C.A.B. Jahoda, R. N. Zuckermann, G. J. Sharples*, S.L. Cobb* “Exploring the links between peptoid antibacterial activity and toxicity” MedChemComm. 2017, 8(5), 886-896


Bolt HL, Eggimann GA, Denny PW,* and Cobb SL.,* "Enlarging the chemical space of anti-leishmanials: a structure-activity relationship study of peptoids against Leishmania mexicana, a causative agent of cutaneous leishmania". MedChemComm., 2016, 7, 799-805

Want to know more about our work on Neglected Tropical Diseases? Check out our GCRF / MRC funded Global NTD network page.

 

BIOORGANIC FLUORINE CHEMISTRY

Recent work in this area

WDG Brittain*, SL Cobb* “Tetrafluoropyridyl (TFP): a general phenol protecting group readily cleaved under mild conditions” Org. Biomol. Chem., 2019, 17 (8), 2110-2115

D. Gimenez, C.A. Mooney, A. Dose, G. Sandford, C. R. Coxon and S.L. Cobb* “The application of perfluoroheteroaromatic reagents in the preparation of modified peptide systems” Org. Biomol. Chem., 2017, 15, 4086-4095

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CANCER RESEARCH

Recent work in this area

L. Jiang, R. Lan, T. Huang, C.-F. Chan, H. Li, S. Lear, J. Zong, W.-Y. Wong, M. M.-Lan Lee, B. D. Chan, W.-L. Chan, W.-S. Lo, N.-K. Mak,* M. L. Lung, G. S. Taylor, Z.-X. Bian, W. C. S. Tai, G.-L. Law*, W.-T. Wong, S.L. Cobb,* and K.-L. Wong,* “EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus”, Nat. Biomed. Eng., 2017, 0042.